0704-883-0675     |      dataprojectng@gmail.com

EFFECT OF CHRONOMODULATED ARTESUNATE ON RENAL AND HAEMATOLOGICAL TOXICITY IN CISPLATIN-TREATED WISTAR RATS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 5000

ABSTRACT

Cisplatin is a non-cell-cycle dependent chemotherapeutic agent used in the treatment of several common solid tumours. However, an array of serious toxicities in various organs and systems limit its therapeutic use. Artesunate, a semisynthetic derivative of artemisinin is the recommended treatment by the WHO for severe and complicated malaria in low-transmission areas and in the second and third trimesters of pregnancy. In contrast, animal experiments show considerable toxicity upon administration of artemisinins. When malaria and cancer coexist, treatment of patients could be challenging due to the burden of disease and possible drug-drug interaction. The present study investigates the effect of 7-day chronomodulated artesunate administration on renal and haematological toxicity in cisplatin-treated rats. Four groups (n=7/group) of rats received intraperitoneal (i.p.) injection of 3 mg/kg daily dosing of cisplatin at four equispaced circadian times (00:00, 06:00, 12:00 and 18:00 h), for four days to determine the time of least renal and hematological toxicity. Another, two groups of rats (n=7/group) pre-treated with cisplatin (3 mg/kg i.p.) at 06:00 h received artesunate (60 mg/kg i.p.) at 12:00 h and 18:00 h. Parameters of the kidney function, histology of the kidneys and haematological variables were measured on day-8. Post-treatment results showed that administration of cisplatin at 06:00 h and 18:00 h appeared to produce least renal and haematological toxicity. However, kidney function as determined by urea and creatinine levels were not significantly (p>0.05) different between cisplatin-artesunate treated groups and saline control rats.. The group pre-treated with cisplatin and then artesunate at 12:00 h had higher (p<0.05) mean magnesium levels when compared to the saline control and the group pre-treated with cisplatin and then artesunate at 18:00 h. This is indicative of a less protective effect of time of artesunate administration, which is consistent with the impaired kidney histologic architecture observed. The red blood cell (RBC) and haemoglobin (HGB) vi counts were unaffected in cisplatin-artesunate treatment groups irrespective of the time of artesunate administration. However, cisplatin-treated rats that received artesunate at 12:00 h had slightly higher RBC and HGB values indicative of enhanced erythropoiesis. A reduction (p<0.05) in mean serum levels of white blood cell (WBC), platelets (PLT) and lymphocytes (LYM) was observed in both groups of rats pretreated with cisplatin and then artesunate at 12:00 h or 18:00 h. Conversely, neutrophils and monocytes (granulocytes) in these groups had higher (p<0.05) mean values indicative of time dependent immune reconstitution. The ameliorative effect of late activity span cisplatin-treatment on renal and haematological toxicity in wistar rats does not appear to be negated by 7-day chronomodulated daily administration of artesunate. However, this study illustrated the potential therapeutic value of time dependent administration of artesunate in contributing to the ameliorative effect of late activity span cisplatin dosing.





Related Project Materials

The Effect of High Sugar Intake on Insulin Resistance in Taraba State

Background of the Study

Insulin resistance is a major precursor to type 2 diabetes and other metabolic...

Read more
INFLUENCE OF PARENTAL ATTITUDE ON THE ACADEMIC PERFORMANCE OF UPPER BASIC STUDENTS IN MAKURDI LOCAL GOVT AREA

Background of t

An Investigation of Nurses' Knowledge and Adherence to Ethical Principles in Patient Care at Olabisi Onabanjo University Teaching Hospital

Background of the Study
Ethical principles are fundamental in guiding healthcare practices, ensuring that patient care is d...

Read more
The impact of urbanization on groundwater depletion in Maiduguri Local Government Area, Borno State

Background of the Study

Urbanization is a global phenomenon that brings about significant changes in land use, infrastructure development...

Read more
Investigation into the Effectiveness of CAPTCHA in Preventing Automated Attacks: A Case Study of Ibrahim Badamasi Babangida University, Lapai (Lapai LGA, Niger State)

Background of the Study
CAPTCHA (Completely Automated Public Turing test to tell Computers and Humans Apart) is a security...

Read more
An examination of the accessibility of online learning for economically disadvantaged students in Gusau Central LGA, Zamfara State

Background of the Study

Online learning has emerged as a transformative approach to education, offering flexibility and access to diverse...

Read more
ASSESSING THE MERITS OF POLICE REFORMATION IN IMPROVING NATIONAL SECURITY: A CASE STUDY OF THE 2020 ENDSARS PROTEST

ABSTRACT

This study was undertaken to assess the merits associated with police reformation and its impl...

Read more
The Financial Impact of CSR on Corporate Performance: A Case Study of MTN Nigeria

Background of the Study

Corporate Social Responsibility (CSR) has become an essential strategy for companies globally, including in Niger...

Read more
IMPACT OF TWITTER BAN ON ELECTRONIC MEDIA IN NIGERIA ( A CASE STUDY OF ARISE TV AND CHANNELS TV)

ABSTRACT

The basic aim of this study is to examine the effect of twitter ban on electronic media using Arise and...

Read more
The Role of Photography in Documenting Traditional Crafts in Argungu Local Government Area, Kebbi State

Chapter One: Introduction

1.1 Background of the Study

Share this page with your friends




whatsapp